Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence.
Uncovering the dominant molecular deregulation among the multitude of pathways implicated in aggressive prostate cancer is essential to intelligently developing targeted therapies. Paradoxically, published prostate cancer gene expression signatures of poor prognosis share little overlap and thus do not reveal shared mechanisms. The authors hypothesize that, by analyzing gene signatures with quantitative models of protein-protein interactions, key pathways will be elucidated and shown to be shared.
Author(s): Chen, James L, Li, Jianrong, Stadler, Walter M, Lussier, Yves A
DOI: 10.1136/amiajnl-2011-000178